Article
Conformational Control of Cascade Interference and Priming Activities in CRISPR Immunity.
Molecular cell - 17 Nov 2016
Xue Chaoyou, Whitis Natalie R, Sashital Dipali G
Abstract excerpt
During type I-E CRISPR-Cas immunity, the Cascade surveillance complex utilizes CRISPR-derived RNAs to target complementary invasive DNA for destruction. When invader mutation blocks this interference activity, Cascade instead triggers rapid primed adaptation against the invader. The molecular basis for this dual Cascade activity is poorly understood. Here we show that the conformation of the Cse1 subunit controls...
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