Genetically diverse influenza antibodies highlight the role of IG germline gene variation and inform population-comprehensive vaccine strategies.

doi:10.1016/j.immuni.2026.03.002

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Article

Genetically diverse influenza antibodies highlight the role of IG germline gene variation and inform population-comprehensive vaccine strategies.

Immunity - 14 Apr 2026

Fischer Alexandra A, Corcoran Martin, Brouwer Philip J M, Chernyshev Mark, Gillespie Rebecca A, Nicoletto Andrea, Loeffler Johannes R, Ferguson James A, Zygouras Ioannis, Pushparaj Pradeepa, Rodriguez Alesandra J, Narang Sanjana, van Gils Marit J, Castro Dopico Xaquin, Kanekiyo Masaru, Ward Andrew B, Han Julianna, Karlsson Hedestam Gunilla B

Abstract excerpt

The regular emergence of influenza strains with pandemic potential necessitates vaccines that elicit protective immune responses across genetically diverse human populations. A critical but understudied factor is how germline-encoded variation in immunoglobulin genes shapes the development of neutralizing antibodies. Here, by combining personalized immunoglobulin genotyping with high-throughput paired-chain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41895293
DOI: 10.1016/j.immuni.2026.03.002
PMCID: PMC13110342

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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