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Article

Environmental conditions dictate differential evolution of vancomycin resistance in Staphylococcus aureus.

Communications biology - 25 Jun 2021

Machado Henrique, Seif Yara, Sakoulas George, Olson Connor A, Hefner Ying, Anand Amitesh, Jones Ying Z, Szubin Richard, Palsson Bernhard O, Nizet Victor, Feist Adam M

Abstract excerpt

While microbiological resistance to vancomycin in Staphylococcus aureus is rare, clinical vancomycin treatment failures are common, and methicillin-resistant S. aureus (MRSA) strains isolated from patients after prolonged vancomycin treatment failure remain susceptible. Adaptive laboratory evolution was utilized to uncover mutational mechanisms associated with MRSA vancomycin resistance in a physiological medium...

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Share to Antimicrobial Resistance in Staphylococcus
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34172889
DOI: 10.1038/s42003-021-02339-z
PMCID: PMC8233327

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