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Article

Morphological, genomic and transcriptomic responses of Klebsiella pneumoniae to the last-line antibiotic colistin.

Scientific reports - 29 Jun 2018

Cain Amy K, Boinett Christine J, Barquist Lars, Dordel Janina, Fookes Maria, Mayho Matthew, Ellington Matthew J, Goulding David, Pickard Derek, Wick Ryan R, Holt Kathryn E, Parkhill Julian, Thomson Nicholas R

Abstract excerpt

Colistin remains one of the few antibiotics effective against multi-drug resistant (MDR) hospital pathogens, such as Klebsiella pneumoniae. Yet resistance to this last-line drug is rapidly increasing. Characterized mechanisms of colR in K. pneumoniae are largely due to chromosomal mutations in two-component regulators, although a plasmid-mediated colR mechanism has recently been uncovered. However, the effects of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29959380
DOI: 10.1038/s41598-018-28199-y
PMCID: PMC6026146

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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