Article
Polymorphisms in XRCC1, ERCC2, and ERCC3 DNA repair genes, CYP1A1 xenobiotic metabolism gene, and tobacco are associated with bladder cancer susceptibility in Tunisian population.
Environmental science and pollution research international - 1 Oct 2017
Feki-Tounsi Molka, Khlifi Rim, Louati Ibtihel, Fourati Mohamed, Mhiri Mohamed-Nabil, Hamza-Chaffai Amel, Rebai Ahmed
Abstract excerpt
Other than the established environmental risk factors associated with bladder cancer (BC), little is known about the genetic variations determining the individual susceptibility of this complex disease. This study aimed to investigate the relationship of BC with environmental agents and polymorphisms in XRCC1, ERCC2, and ERCC3 DNA repair genes and CYP1A1, CYP2D6, NAT1, and NAT2 xenobiotic metabolism genes through...
Topics
- Adult
- Aged
- Aged, 80 and over
- Arylamine N-Acetyltransferase
- Case-Control Studies
- Cytochrome P-450 CYP1A1
- DNA Helicases
- DNA Repair
- DNA-Binding Proteins
- Female
- Genetic Predisposition to Disease
- Genotype