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Article

Impact of polygenic schizophrenia-related risk and hippocampal volumes on the onset of psychosis.

Translational psychiatry - 9 Aug 2016

Harrisberger F, Smieskova R, Vogler C, Egli T, Schmidt A, Lenz C, Simon A E, Riecher-Rössler A, Papassotiropoulos A, Borgwardt S

Abstract excerpt

Alterations in hippocampal volume are a known marker for first-episode psychosis (FEP) as well as for the clinical high-risk state. The Polygenic Schizophrenia-related Risk Score (PSRS), derived from a large case-control study, indicates the polygenic predisposition for schizophrenia in our clinical sample. A total of 65 at-risk mental state (ARMS) and FEP patients underwent structural magnetic resonance imaging....

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Identifiers

PMID: 27505231
DOI: 10.1038/tp.2016.143
PMCID: PMC5022088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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