Article
Association of genetic risks for schizophrenia and bipolar disorder with specific and generic brain structural endophenotypes.
Archives of general psychiatry - 1 Oct 2004
McDonald Colm, Bullmore Edward T, Sham Pak C, Chitnis Xavier, Wickham Harvey, Bramon Elvira, Murray Robin M
Abstract excerpt
CONTEXT: For more than a century, it has been uncertain whether or not the major diagnostic categories of psychosis--schizophrenia and bipolar disorder--are distinct disease entities with specific genetic causes and neuroanatomical substrates. OBJECTIVE: To investigate the relationship between genetic risk and structural variation throughout the entire brain in patients and their unaffected relatives sampled from...
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