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Nucleophile Promiscuity of Natural and Engineered Aldolases.

Chembiochem : a European journal of chemical biology - 4 Jul 2018

Hernández Karel, Szekrenyi Anna, Clapés Pere

Abstract excerpt

The asymmetric aldol addition reaction mediated by aldolases is recognized as a green and sustainable method for carbon-carbon bond formation. Research in this area has unveiled their unprecedented synthetic potential toward diverse, new chemical structures; novel product families; and even as a technology for industrial manufacturing processes. Despite these advances, aldolases have long been regarded as...

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PMID: 29645339
DOI: 10.1002/cbic.201800135

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