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Article

Chromatin remodeller CHD7 is required for GABAergic neuron development by promoting PAQR3 expression.

EMBO reports - 4 Jun 2021

Jamadagni Priyanka, Breuer Maximilian, Schmeisser Kathrin, Cardinal Tatiana, Kassa Betelhem, Parker J Alex, Pilon Nicolas, Samarut Eric, Patten Shunmoogum A

Abstract excerpt

Mutations in the chromatin remodeller-coding gene CHD7 cause CHARGE syndrome (CS). CS features include moderate to severe neurological and behavioural problems, clinically characterized by intellectual disability, attention-deficit/hyperactivity disorder and autism spectrum disorder. To investigate the poorly characterized neurobiological role of CHD7, we here generate a zebrafish chd7-/- model. chd7-/- mutants...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33900016
DOI: 10.15252/embr.202050958
PMCID: PMC8183419

Genes

CHD7
CS
PAQR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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