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Article

α-Synuclein Disrupts Vesicle Fusion by Two Mutant-Specific Mechanisms.

Molecules and cells - 30 Nov 2022

Yoo Gyeongji, An Hyeong Jeon, Yeou Sanghun, Lee Nam Ki

Abstract excerpt

Synaptic accumulation of α-synuclein (α-Syn) oligomers and their interactions with VAMP2 have been reported to be the basis of synaptic dysfunction in Parkinson's disease (PD). α-Syn mutants associated with familial PD have also been known to be capable of interacting with VAMP2, but the exact mechanisms resulting from those interactions to eventual synaptic dysfunction are still unclear. Here, we investigate the...

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Identifiers

PMID: 36380732
DOI: 10.14348/molcells.2022.0102
PMCID: PMC9676983

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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