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RNA Splicing of the FGFR2 Gene Promotes Endothelial Cell Senescence and Atherosclerosis Development.

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2026

Ni Qihong, Qi Haozhe, Chu Yinteng, Cao Ruzhou, Wang Yuli, Yang Shuofei, Yao Yongjie, Wang Hai, Yuan Kai, Lv Lei, Ye Meng, Xue Guanhua, Zhang Lan, Guo Xiangjiang, Li Yinan

Abstract excerpt

BACKGROUND: Endothelial cell (EC) senescence is intimately linked to the development and progression of atherosclerosis. The FGFR2 (fibroblast growth factor receptor 2) signaling is crucial in regulating the phenotype of ECs. Recent studies have revealed that cell phenotype-specific alternative splicing of FGFR2 premRNA (precursor mRNA) results in the mutually exclusive inclusion of either exon IIIb or IIIc,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Human Umbilical Vein Endothelial Cells

Share to Mice, Knockout, ApoE

Share to Plaque, Atherosclerotic

Share to Receptor, Fibroblast Growth Factor, Type 2

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Source

Identifiers

PMID: 41853867
DOI: 10.1161/ATVBAHA.125.323834

Genes

FGFR2
FGF2
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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