Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endothelial<i>Cdkn1a</i>(<i>p21</i>) Overexpression and Accelerated Senescence in a Mouse Model of Fuchs Endothelial Corneal Dystrophy

7 Sept 2012

Abstract excerpt

PURPOSE: Stress of the endoplasmic reticulum and oxidative stress play critical roles in the pathogenesis of Fuchs Endothelial Corneal Dystrophy (FECD). In the normal aging cornea, cellular stress has been associated with a loss in proliferative capacity (premature senescence) of corneal endothelial cells (CECs). The present study used a transgenic Col8a2(Q455K/Q455K) knock-in mouse model of early-onset FECD to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Corneal surgery and disorders
Share to Corneal Surgery and Treatments
Share to Ocular Surface and Contact Lens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22956607
DOI: 10.1167/iovs.12-9669

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endothelial<i>Cdkn1a</i>(<i>p21</i>) Overexpression and Accelerated Senescence in a Mouse Model of Fuchs Endothelial Corneal DystrophyPMID 22956607Read ↗

Early Transcriptomic and Pathologic Changes of Col8a2 Mutant Fuchs Endothelial Corneal Dystrophy.Semantic proximity Read ↗

Preclinical Models for Studying Fuchs Endothelial Corneal DystrophySemantic proximity Read ↗

Endothelial cell whole genome expression analysis in a mouse model of early-onset Fuchs' endothelial corneal dystrophy.Semantic proximity Read ↗

L450W and Q455K Col8a2 knock-in mouse models of Fuchs endothelial corneal dystrophy show distinct phenotypes and evidence for altered autophagy.Semantic proximity Read ↗

An alpha 2 collagen VIII transgenic knock-in mouse model of Fuchs endothelial corneal dystrophy shows early endothelial cell unfolded protein response and apoptosis.Semantic proximity Read ↗

Heterogeneity of human corneal endothelium implicates lncRNA NEAT1 in Fuchs endothelial corneal dystrophySemantic proximity Read ↗

Long term high glucose exposure induces premature senescence in retinal endothelial cellsSemantic proximity Read ↗

Proteasomal Dysfunction results in ER stress, Endo MT, oxidative stress, and apoptotic cell death resulting in Fuchs Corneal Endothelial Dystrophy like features in miceSemantic proximity Read ↗

Age-related dystrophic changes in corneal endothelium from DNA repair-deficient mice.Semantic proximity Read ↗

TAZ ( <i>Wwtr1</i> ) deficiency leads to ER stress and mitochondrial dysfunction in a mouse model of Fuchs’ endothelial corneal dystrophySemantic proximity Read ↗

Characterization of a novel mouse model for Fuchs Endothelial Corneal DystrophySemantic proximity Read ↗

RNA-Seq–based transcriptome analysis of corneal endothelial cells derived from patients with Fuchs endothelial corneal dystrophySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.