Article
Endothelial Cell Senescence in Marfan Syndrome: Pathogenesis and Therapeutic Potential of TGF-β Pathway Inhibition.
Journal of the American Heart Association - 6 May 2025
Chen Yuhao, Zhu Yuankang, Ren Xiaoli, Ding Lu, Xu Yubin, Zhou Miqi, Dong Runze, Jin Peifeng, Chen Xiufang, Fan Xiaofang, Li Ming, Gong Yongsheng, Wang Yongyu
Abstract excerpt
BACKGROUND: Marfan syndrome (MFS) is a heritable connective tissue disorder caused by mutations in the Fibrillin-1 gene, which encodes the extracellular matrix protein fibrillin-1. Patients with MFS are predisposed to aortic aneurysms and dissections, significantly contributing to mortality. Emerging evidence suggests that endothelial cell (EC) senescence plays a critical role in the pathogenesis of aortic...
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