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Article

Alteration of E2F2 Expression in Governing Endothelial Cell Senescence

24 Aug 2022

Abstract excerpt

Endothelial cell senescence has a vital implication for vascular dysfunction, leading to age-related cardiovascular disease, especially hypertension and atherosclerosis. E2F transcription factor 2 (E2F2) plays a critical role in cell proliferation, differentiation, and DNA damage response. Up to date, no study has ever connected E2F2 to vascular endothelial cell senescence. Here, we demonstrate that E2F2 is...

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PMID: 36140689
DOI: 10.3390/genes13091522

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