Article
FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence.
Bone - 1 Jul 2010
Krejci Pavel, Prochazkova Jirina, Smutny Jiri, Chlebova Katarina, Lin Patricia, Aklian Anie, Bryja Vitezslav, Kozubik Alois, Wilcox William R
Abstract excerpt
Oncogenic activation of the RAS-ERK MAP kinase signaling pathway can lead to uncontrolled proliferation but can also result in apoptosis or premature cellular senescence, both regarded as natural protective barriers to cell immortalization and transformation. In FGFR3-related skeletal dyplasias, oncogenic mutations in the FGFR3 receptor tyrosine kinase cause profound inhibition of cartilage growth resulting in...
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