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Article

CircRREB1 mediates lipid metabolism related senescent phenotypes in chondrocytes through FASN post-translational modifications.

Nature communications - 28 Aug 2023

Gong Zhe, Zhu Jinjin, Chen Junxin, Feng Fan, Zhang Haitao, Zhang Zheyuan, Song Chenxin, Liang Kaiyu, Yang Shuhui, Fan Shunwu, Fang Xiangqian, Shen Shuying

Abstract excerpt

Osteoarthritis is a prevalent age-related disease characterized by dysregulation of extracellular matrix metabolism, lipid metabolism, and upregulation of senescence-associated secretory phenotypes. Herein, we clarify that CircRREB1 is highly expressed in secondary generation chondrocytes and its deficiency can alleviate FASN related senescent phenotypes and osteoarthritis progression. CircRREB1 impedes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37640697
DOI: 10.1038/s41467-023-40975-7
PMCID: PMC10462713

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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