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Article

ABCC2 rs2273697 is an independent determinant of tacrolimus intra-patient variability during the first year after kidney transplantation.

International journal of clinical pharmacy - 1 Aug 2026

You Jia, Liu Hongxia, Yang Yunyun, Fu JiaZhao, Sui Mingxing, Zhao Wenyu, Yuan Zhilong, Ma Tao, Wang Zhuo, Wang Xuebin

Abstract excerpt

INTRODUCTION: Tacrolimus is a critical immunosuppressive agent in kidney transplantation, but its pharmacokinetic variability, especially intra-patient variability (IPV), can lead to suboptimal outcomes. Genetic polymorphisms in CYP3A5 and ABCC2 may influence tacrolimus metabolism and transport, affecting dosing requirements and IPV. However, their combined impact during the first year after kidney...

Topics

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Cohort Studies
Cytochrome P-450 CYP3A
CYP3A5 gene
Immunosuppressive Agents
Kidney Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multidrug Resistance-Associated Protein 2

Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 41849095
DOI: 10.1007/s11096-026-02117-z
PMCID: PMC13368854

Genes

ABCC2
CYP3A5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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ABCC2 rs2273697 is an independent determinant of tacrolimus intra-patient variability during the first year after kidney transplantation.PMID 41849095Read ↗

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