Article
Combined Effect of Inter- and Intrapatient Variability in Tacrolimus Exposure on Graft Impairment Within a 3-Year Period Following Kidney Transplantation: A Single-Center Experience.
European journal of drug metabolism and pharmacokinetics - 1 Dec 2020
Stefanović Nikola Z, Veličković-Radovanović Radmila M, Danković Katarina S, Mitić Branka P, Paunović Goran J, Cvetković Mina B, Cvetković Tatjana P
Abstract excerpt
BACKGROUND AND OBJECTIVE: Tacrolimus is a cornerstone of the most immunosuppressive protocols after kidney transplantation, but its use is complicated by notable interpatient and intrapatient variability (IPV). The goal of this study was to evaluate whether or not tacrolimus IPV, or average dose-adjusted trough concentration (C0/D), during 6-12 months post-transplantation might have contributed to graft function...
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