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Article

Influence of CYP3A4 and CYP3A5 polymorphisms on tacrolimus and sirolimus exposure in stable kidney transplant recipients.

Drug metabolism and personalized therapy - 24 May 2017

Tamashiro Erika Y, Felipe Claudia R, Genvigir Fabiana D V, Rodrigues Alice C, Campos Antony B, Hirata Rosario D C, Tedesco-Silva Helio, Medina-Pestana Jose O

Abstract excerpt

BACKGROUND: Polymorphisms in genes encoding for drug-metabolizing enzymes and drug transporters are among multiple factors that modulate the pharmacokinetic variability of tacrolimus (TAC) and sirolimus (SRL). This study aimed to evaluate the influence of single nucleotide polymorphisms (SNPs) on TAC and SRL dose-adjusted concentrations (C0/D) in stable kidney transplant recipients. METHODS: This is an...

Read the complete abstract on PubMed

Topics

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Share to Cytochrome P-450 CYP3A
Share to Erythropoietin and Anemia Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ABCB1 gene

Share to Kidney Transplantation

Share to Polymorphism, Single Nucleotide

Share to Renal Transplantation Outcomes and Treatments

Share to Sirolimus

Share to Tacrolimus

Source

Identifiers

PMID: 28593920
DOI: 10.1515/dmpt-2016-0036

Genes

SRL
ABCB1

Variants

rs10509681
rs1128503
rs2032582
rs1045642

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Influence of CYP3A4 and CYP3A5 polymorphisms on tacrolimus and sirolimus exposure in stable kidney transplant recipients.PMID 28593920Read ↗

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