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Article

Effects of CYP3A4, CYP3A5, and ABCB1 genetic variants on tacrolimus metabolism during the early period after kidney transplantation.

The pharmacogenomics journal - 30 Jul 2026

Dukaew Nahathai, Noppakun Kajohnsak, Na Takuathung Mingkwan, Kongta Nattharinee, Inpan Ratchanon, Suyayai Naruemon, Koonrungsesomboon Nut

Abstract excerpt

Tacrolimus (TAC) exhibits substantial interindividual pharmacokinetic variability, complicating early dose optimization after kidney transplantation. This study evaluated the effects of CYP3A5 rs776746 (6986A > G), CYP3A4 rs4646437 (G > A), and ABCB1 rs1045642 (3435C > T) genetic variations on TAC metabolism during the first post-transplant month. In 120 kidney transplant recipients, TAC exposure was assessed...

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Topics

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to Cytochrome P-450 CYP3A
Share to CYP3A5 gene
Share to Genotype
Share to Immunosuppressive Agents
Share to Kidney Transplantation
Share to Polymorphism, Single Nucleotide
Share to Tacrolimus

Source

Identifiers

PMID: 42527396
DOI: 10.1038/s41397-026-00427-z

Genes

CYP3A4
CYP3A5
ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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Effects of CYP3A4, CYP3A5, and ABCB1 genetic variants on tacrolimus metabolism during the early period after kidney transplantation.PMID 42527396Read ↗

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