The Impact of CYP3A4*22 on Tacrolimus Pharmacokinetics and Outcome in Clinical Practice at a Single Kidney Transplant Center

Abstract excerpt

Although there is evidence that the CYP3A4*22 variant should be considered in tacrolimus dosing in renal transplantation, its impact beyond tacrolimus dose requirements remains controversial. Methods In a cohort of 121 kidney transplant recipients, we analyzed the CYP3A4*1B, CYP3A4*22, CYP3A5*3 alleles and the ABCB1 variants 1236C>T, 2677G>T/A, 3435C>T for their impact on exposure and dose requirement. Relevant...

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