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Article

The role of single nucleotide polymorphisms of CYP3A and ABCB1 on tacrolimus predose concentration in kidney transplant recipients.

Clinical nephrology - 1 Jan 2000

Mlinšek Gregor, Dolžan Vita, Goričar Katja, Buturović-Ponikvar Jadranka, Arnol Miha

Abstract excerpt

BACKGROUND: Tacrolimus has a narrow therapeutic drug window but high inter- and intrapatient variability. Our aim is to construct a model able to predict optimal maintenance tacrolimus predose concentration (C0) in kidney transplant patients. Here we present our study design and genotype and variant allele frequencies for the selected single nucleotide polymorphisms of genes involved in tacrolimus metabolism in...

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to Cross-Sectional Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP3A

Share to Gene Frequency

Share to Immunosuppressive Agents

Share to Kidney Transplantation

Share to Polymorphism, Single Nucleotide

Share to Tacrolimus

Source

Identifiers

PMID: 28655393
DOI: 10.5414/CNP88FX25

Genes

ABCB1

Provenance

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