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Article

Impact of tacrolimus intraindividual variability and CYP3A5 genetic polymorphism on acute rejection in kidney transplantation.

Therapeutic drug monitoring - 1 Dec 2012

Ro Han, Min Sang-Il, Yang Jaeseok, Moon Kyung Chul, Kim Yon Su, Kim Sang Joon, Ahn Curie, Ha Jongwon

Abstract excerpt

BACKGROUND: Wide variation in tacrolimus concentrations and low tacrolimus exposure have been reported to be associated with poor renal graft outcomes in non-Asians. The CYP3A5 polymorphism is a representative genetic factor that might affect this association, together with environmental factors. We investigated whether tacrolimus variability or the mean tacrolimus trough concentration can influence kidney...

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Cytochrome P-450 CYP3A
Drug Resistance
Graft Rejection
Immunosuppressive Agents
Kidney Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Republic of Korea

Survival Analysis

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PMID: 23149441
DOI: 10.1097/FTD.0b013e3182731809

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Impact of tacrolimus intraindividual variability and CYP3A5 genetic polymorphism on acute rejection in kidney transplantation.PMID 23149441Read ↗

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