Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased alcohol drinking and seizure susceptibility in female humanized ApoE4 knockin rats.

Physiology & behavior - 1 Jun 2026

Choi Chan Young, Venegas Jassmyn J, Rauch Sarah M, Walter Francis A, Ryan Joel N, Machireddy Mythili, Weisz Jacob M, Tracy Gregory C, Baker Annie J, Floresco Stan B, Chung Hee Jung, Liang Nu-Chu

Abstract excerpt

Epidemiological analyses suggest that the Ɛ4 allele of apolipoprotein E (ApoE) genes may influence the effects of alcohol on cognitive and executive function and dementia risk compared to the Ɛ3 allele. Here, we investigated this question in female rats given that women are more vulnerable than men to the Ɛ4 genotype effects on various diseases. Experiment 1 examined the effects of alcohol drinking on performance...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein E3
Share to Conditioning, Operant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ethanol

Share to Executive Function

Share to Gene Knock-In Techniques

Share to Kainic Acid

Share to Maze Learning

Share to Rats, Transgenic

Source

Open in PubMed Open full text

Identifiers

PMID: 41833783
DOI: 10.1016/j.physbeh.2026.115308
PMCID: PMC13123892

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased alcohol drinking and seizure susceptibility in female humanized ApoE4 knockin rats.PMID 41833783Read ↗

Characterizing the human APOE epsilon 4 knock-in transgene in female and male rats with multimodal magnetic resonance imaging.Semantic proximity Read ↗

Effects of sex and genotype in human APOE-targeted replacement mice on alcohol self-administration measured with the automated IntelliCage system before and after repeated mild traumatic brain injury.Semantic proximity Read ↗

Characterizing the human APOE epsilon 4 knock-in transgene in female and male rats with multimodal magnetic resonance imagingSemantic proximity Read ↗

Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females.Semantic proximity Read ↗

Contributions of sex and genotype to exploratory behavior differences in an aged humanized APOE mouse model of late-onset Alzheimer's disease.Semantic proximity Read ↗

Apolipoprotein E (APOE) genotype and the pesticide chlorpyrifos modulate attention, motivation and impulsivity in female mice in the 5-choice serial reaction time task.Semantic proximity Read ↗

Intermittent short- and long-term alcohol exposures influence alcohol consumption, anxiety-like behaviors, and seizure onset in genetically epilepsy-prone rats.Semantic proximity Read ↗

Reduction of APOE accounts for neurobehavioral deficits in fetal alcohol spectrum disorders.Semantic proximity Read ↗

Understanding the addiction cycle: a complex biology with distinct contributions of genotype vs. sex at each stage.Semantic proximity Read ↗

Apolipoprotein E isoform-dependent effects on anxiety and cognition in female TR mice.Semantic proximity Read ↗

Human Apolipoprotein E Genotype Differentially Affects Olfactory Behavior and Sensory Physiology in Mice.Semantic proximity Read ↗

APOE4 rat model of Alzheimer's disease: sex differences, genetic risk and diet.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.