Intermittent short- and long-term alcohol exposures influence alcohol consumption, anxiety-like behaviors, and seizure onset in genetically epilepsy-prone rats.

doi:10.1016/j.alcohol.2025.10.002

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Article

Intermittent short- and long-term alcohol exposures influence alcohol consumption, anxiety-like behaviors, and seizure onset in genetically epilepsy-prone rats.

Alcohol (Fayetteville, N.Y.) - 1 Dec 2025

Silva-Cardoso Gleice Kelli, N'Gouemo Prosper

Abstract excerpt

The genetically epilepsy-prone rats (GEPR-3s) are known for their hereditary susceptibility to seizures and anxiety. This study investigates the impact of short-term (1 week) and long-term (4 weeks) intermittent alcohol exposure through a two-bottle choice paradigm on voluntary alcohol intake, anxiety-like behaviors, and acoustically evoked seizure susceptibility in the GEPR-3s. Anxiety behaviors were assessed...

Topics

Animals
Anxiety
Male
Alcohol Drinking
Female
Rats
Seizures
Ethanol
Epilepsy
Time Factors
Genetic Predisposition to Disease
Behavior, Animal

Source

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Identifiers

PMID: 41047108
DOI: 10.1016/j.alcohol.2025.10.002
PMCID: PMC12560620

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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