Article
Effects of sex and genotype in human APOE-targeted replacement mice on alcohol self-administration measured with the automated IntelliCage system before and after repeated mild traumatic brain injury.
Alcoholism, clinical and experimental research - 1 Nov 2021
Simmons Kathryn E, Healey Kati L, Li Qiang, Moore Scott D, Klein Rebecca C
Abstract excerpt
BACKGROUND: Few studies have examined the association between APOE genotype and alcohol use. Although some of these studies have reported outcomes associated with a history of drinking, none have examined alcohol-seeking behavior. In addition, no preclinical studies have examined alcohol use as a function of APOE genotype with or without traumatic brain injury. METHODS: Male and female human APOE3- and...
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