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Article

Understanding the addiction cycle: a complex biology with distinct contributions of genotype vs. sex at each stage.

Neuroscience - 24 Oct 2014

Wilhelm C J, Hashimoto J G, Roberts M L, Sonmez M K, Wiren K M

Abstract excerpt

Ethanol abuse can lead to addiction, brain damage and premature death. The cycle of alcohol addiction has been described as a composite consisting of three stages: intoxication, withdrawal and craving/abstinence. There is evidence for contributions of both genotype and sex to alcoholism, but an understanding of the biological underpinnings is limited. Utilizing both sexes of genetic animal models with highly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25194791
DOI: 10.1016/j.neuroscience.2014.08.041
PMCID: PMC4224688

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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