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Article

Beyond HLA: An adaptive nanopore sequencing assay for simultaneous HLA and blood group profiling in transplantation.

Human immunology - 1 May 2026

Grasedieck S, McIntyre L, Roulis E, Hamadeh Z, Murphey C, Lane W J, Keown P A, Sherwood K R

Abstract excerpt

AIM: Transplantation is a life-saving therapy but carries significant risks, including rejection, graft-versus-host disease, infection, and malignancy, which can lead to graft failure and death. These complications arise from the interaction between the recipient's immune system and the transplanted organ, requiring long-term toxic drugs to prevent immune injury. Traditional genetic pre-transplant assessment...

Topics

Humans
HLA Antigens
Nanopore Sequencing
Histocompatibility Testing
Graft Rejection
Genotype
Blood Grouping and Crossmatching
Organ Transplantation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 41831333
DOI: 10.1016/j.humimm.2026.111710

Genes

ABO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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