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Article

Long-Read Nanopore Sequencing Validated for Human Leukocyte Antigen Class I Typing in Routine Diagnostics.

The Journal of molecular diagnostics : JMD - 1 Jul 2020

Matern Benedict M, Olieslagers Timo I, Groeneweg Mathijs, Duygu Burcu, Wieten Lotte, Tilanus Marcel G J, Voorter Christina E M

Abstract excerpt

Matching of human leukocyte antigen (HLA) gene polymorphisms by high-resolution DNA sequence analysis is the gold standard for determining compatibility between patient and donor for hematopoietic stem cell transplantation. Single-molecule sequencing (PacBio or MinION) is a newest (third) generation sequencing approach. MinION is a nanopore sequencing platform, which provides long targeted DNA sequences. The long...

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Identifiers

PMID: 32302780
DOI: 10.1016/j.jmoldx.2020.04.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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