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Article

Proof-of-principle: nanopore adaptive sampling enables full blood group genome analysis and resolution of hybrid alleles.

Blood advances - 10 Feb 2026

Gueuning Morgan, Thun Gian Andri, Koller Samuel, Sigurdardottir Sonja, Trost Nadine, Wagner Lukas, Mayer Beate, Engström Charlotte, Mattle-Greminger Maja Patricia, Meyer Stefan

Abstract excerpt

ABSTRACT: Adaptive sampling (AS), a computational enrichment method developed for Oxford Nanopore Technologies sequencing platforms, offers a promising advance in molecular blood group diagnostics. By leveraging long-read sequencing, AS has the potential to accurately resolve complex structural variants in the RH and MNS blood group systems, while characterizing the entire blood group genome through a simple,...

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Identifiers

PMID: 41213005
DOI: 10.1182/bloodadvances.2025017463
PMCID: PMC12887796

Genes

RHD

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