Article
Revolutionising High Resolution HLA Genotyping for Transplant Assessment: Validation, Implementation and Challenges of Oxford Nanopore Technologies' Q20+ Sequencing.
HLA - 1 Oct 2024
El-Lagta Naser, Truong Linh, Ayora Felipe, Mobegi Fredrick, Bruce Samuel, Martinez Patricia, D'Orsogna Lloyd, De Santis Dianne
Abstract excerpt
The advent of third-generation sequencing (TGS) represents a significant shift in the field of genetic sequencing, enabling single-molecule sequencing to overcome limitations of short-read NGS platforms. Several studies have assessed the utilisation of TGS in HLA genotyping, though many of these studies have described the high error rate as an obstacle to achieving a robust and highly accurate HLA typing assay....
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