Article
Two-field resolution on-call HLA typing for deceased donors using nanopore sequencing.
HLA - 1 Mar 2024
Devriese Magali, Da Silva Sephora, Le Mene Melchior, Rouquie Julien, Allain Vincent, Kolesar Libor, Rigo Krisztina, Creary Lisa E, Lauterbach Nina, Usureau Cedric, Dewez Mathieu, Caillat-Zucman Sophie, Werner Gregory, Taupin Jean-Luc
Abstract excerpt
The current practice of HLA genotyping in deceased donors poses challenges due to limited resolution within time constraints. Nevertheless, the assessment of compatibility between anti-HLA sensitized recipients and mismatched donors remains a critical medical need, particularly when dealing with allele-specific (second field genotyping level) donor-specific antibodies. In this study, we present a customized...
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