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Article

Genetic and clinical determinants of tacrolimus accumulation in early liver transplantation: evidence for a combined genotype-antibiotic effect.

Annals of medicine - 1 Dec 2026

Guo Jinlin, Feng Shiying, Feng Zifan, Yang Jinyan, Cai Xinfeng, Li Xingang, Zhang Rui

Abstract excerpt

BACKGROUND: Tacrolimus is a first-line immunosuppressant essential for preventing graft rejection after liver transplantation, but its narrow therapeutic index and extensive interindividual pharmacokinetic variability complicate optimal dosing during the early postoperative phase. METHODS: The pharmacokinetics of tacrolimus were analyzed in liver transplant recipients from longitudinal trough concentrations...

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Source

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Identifiers

PMID: 41821195
DOI: 10.1080/07853890.2026.2643032
PMCID: PMC12990272

Genes

ABCB1
CYP3A4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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Genetic and clinical determinants of tacrolimus accumulation in early liver transplantation: evidence for a combined genotype-antibiotic effect.PMID 41821195Read ↗

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