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Article

Biotransformation enzymes and drug transporters pharmacogenetics in relation to immunosuppressive drugs: impact on pharmacokinetics and clinical outcome.

Transplantation - 15 Apr 2008

Mourad Michel, Wallemacq Pierre, De Meyer Martine, Malaise Jacques, De Pauw Luc, Eddour Djamila Chaïb, Goffin Eric, Lerut Jan, Haufroid Vincent

Abstract excerpt

Immunosuppressive drugs commonly used after organ transplantation to prevent acute rejection including tacrolimus, cyclosporine, sirolimus, and mycophenolic acid are characterized by a narrow therapeutic index and broad interindividual variability in their pharmacokinetics. Adequate immunosuppres...

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Source

Identifiers

PMID: 18401258
DOI: 10.1097/TP.0b013e318169c380

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18401258-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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