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Tacrolimus trough concentrations increase during antibiotherapy despite stable dosing in kidney transplant recipients – a retrospective analysis

2026-08-10

Abstract excerpt

<b>Aim/</b> Kidney transplant recipients (KTR) require lifelong immunosuppression with tacrolimus (TAC), a narrow therapeutic index drug with high intra- and inter-patient pharmacokinetic (PK) variability. Evidence suggests the gut microbiome modulates TAC dose requirements. Given the frequent use of antibiotics in KTR, this study investigates their impact on TAC PK to clarify the microbiome’s role in TAC PK varia...

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Identifiers and source

Literature Corpus work
fb39ba65-d4ef-538c-8b44-cd4957c4ea20
DOI
10.22541/authorea.15007233/v1
Open publication

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Tacrolimus trough concentrations increase during antibiotherapy despite stable dosing in kidney transplant recipients – a retrospective analysisDOI 10.22541/authorea.15007233/v1
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