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Article

Analysis of ABCB1 Gene Polymorphisms and Their Impact on Tacrolimus Blood Levels in Kidney Transplant Recipients.

International journal of molecular sciences - 12 Oct 2024

Rotarescu Corina Andreea, Maruntelu Ion, Rotarescu Ion, Constantinescu Alexandra-Elena, Constantinescu Ileana

Abstract excerpt

Tacrolimus (Tc) is an immunosuppressant used in transplant patients, but its therapeutic range is narrow, making precise dosing essential. This study investigates the association of three single nucleotide polymorphisms (SNPs) (ABCB1 3435C>T, 1236C>T, 2677G>T/A) with Tc levels over time to gain better insights into their role in personalized medicine. We conducted the study over four distinct periods: 1-14 days,...

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Identifiers

PMID: 39456782
DOI: 10.3390/ijms252010999
PMCID: PMC11507373

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Analysis of ABCB1 Gene Polymorphisms and Their Impact on Tacrolimus Blood Levels in Kidney Transplant Recipients.PMID 39456782Read ↗

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