Article
Evolutionary Selection and Constraint on Human Knee Chondrocyte Regulation Impacts Osteoarthritis Risk.
Cell - 16 Apr 2020
Richard Daniel, Liu Zun, Cao Jiaxue, Kiapour Ata M, Willen Jessica, Yarlagadda Siddharth, Jagoda Evelyn, Kolachalama Vijaya B, Sieker Jakob T, Chang Gary H, Muthuirulan Pushpanathan, Young Mariel, Masson Anand, Konrad Johannes, Hosseinzadeh Shayan, Maridas David E, Rosen Vicki, Krawetz Roman, Roach Neil, Capellini Terence D
Abstract excerpt
During human evolution, the knee adapted to the biomechanical demands of bipedalism by altering chondrocyte developmental programs. This adaptive process was likely not without deleterious consequences to health. Today, osteoarthritis occurs in 250 million people, with risk variants enriched in non-coding sequences near chondrocyte genes, loci that likely became optimized during knee evolution. We explore this...
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