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Functional genomics of human skeletal development and the patterning of height heritability

15 Nov 2024

Abstract excerpt

Underlying variation in height are regulatory changes to chondrocytes, cartilage cells comprising long-bone growth plates. Currently, we lack knowledge on epigenetic regulation and gene expression of chondrocytes sampled across the human skeleton, and therefore we cannot understand basic regulatory mechanisms controlling height biology. We first rectify this issue by generating extensive epigenetic and...

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PMID: 39549696
DOI: 10.1016/j.cell.2024.10.040

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