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Article

PD-L1 cell-intrinsic signals limit immune activation during cutaneous vaccinia virus infection.

Journal of immunology (Baltimore, Md. : 1950) - 9 Feb 2026

Kantheti Uma, Shirley Jamie L, Fry Lucy G, Qvale Abrianna M, Olivas-Corral Jessica G, Vankamamidi Sai Eashan, Tamburini Beth Ann Jirón

Abstract excerpt

Negative T-cell regulation through programmed cell death 1 (PD-1)-programmed death ligand 1 (PD-L1) ligation is well described during viral infection; however, our understanding of the contribution of PD-L1-intrinsic signaling to antiviral immunity is limited. Herein, we show that mutation of the PD-L1 intracellular domain results in a dysregulated type 1 interferon (IFN) response in dendritic cells (DCs),...

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Share to B7-H1 Antigen
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41793774
DOI: 10.1093/jimmun/vkaf368
PMCID: PMC13017055

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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