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Article

Vaccinia virus infection induces dendritic cell maturation but inhibits antigen presentation by MHC class II.

Cellular immunology - 1 Apr 2007

Yao Yongxue, Li Ping, Singh Pratibha, Thiele Allison T, Wilkes David S, Renukaradhya Gourapura J, Brutkiewicz Randy R, Travers Jeffrey B, Luker Gary D, Hong Soon-Cheol, Blum Janice S, Chang Cheong-Hee

Abstract excerpt

Vaccinia virus (VV) infection is known to inhibit dendritic cells (DC) functions in vitro. Paradoxically, VV is also highly immunogenic and thus has been used as a vaccine. In the present study, we investigated the effects of an in vivo VV infection on DC function by focusing on early innate immunity. Our data indicated that DC are activated upon in vivo VV infection of mice. Splenic DC from VV-infected mice...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17678637
DOI: 10.1016/j.cellimm.2007.06.005
PMCID: PMC2100387

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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