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Article

CD137L dendritic cells induce potent response against cancer-associated viruses and polarize human CD8+ T cells to Tc1 phenotype.

Cancer immunology, immunotherapy : CII - 1 Jun 2018

Dharmadhikari Bhushan, Nickles Emily, Harfuddin Zulkarnain, Ishak Nur Diana Binte, Zeng Qun, Bertoletti Antonio, Schwarz Herbert

Abstract excerpt

Therapeutic tumor vaccination based on dendritic cells (DC) is safe; however, its efficacy is low. Among the reasons for only a subset of patients benefitting from DC-based immunotherapy is an insufficient potency of in vitro generated classical DCs (cDCs), made by treating monocytes with GM-CSF + IL-4 + maturation factors. Recent studies demonstrated that CD137L (4-1BBL, TNFSF9) signaling differentiates human...

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Share to CD8-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29508025
DOI: 10.1007/s00262-018-2144-x
PMCID: PMC11028277

Genes

AIM2
TNFSF9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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