Article
Programmed Cell Death Ligand (PD-L)-1 Contributes to the Regulation of CD4+ T Effector and Regulatory T Cells in Cutaneous Leishmaniasis.
Frontiers in immunology - 1 Jan 2020
de Freitas E Silva Rafael, Gálvez Rosa Isela, Pereira Valéria Rego Alves, de Brito Maria Edileuza Felinto, Choy Siew Ling, Lotter Hannelore, Bosurgi Lidia, Jacobs Thomas
Abstract excerpt
Cutaneous Leishmaniasis (CL) affects up to one million people every year and treatments are costly and toxic. The regulation of the host immune response is complex and the knowledge of how CD4+ T cells are activated and maintained during Leishmania infection is still limited. Current therapies aim to target programmed cell death (PD)-1 and programmed cell death ligand (PD-L)-1 in order to boost T cell activity....
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