Article
Depletion of PD-1 or PD-L1 did not affect the mortality of mice infected with Mycobacterium avium.
Scientific reports - 9 Sept 2021
Nakajima Masayuki, Matsuyama Masashi, Kawaguchi Mio, Matsumura Sosuke, Kiwamoto Takumi, Matsuno Yosuke, Morishima Yuko, Yoshida Kazufumi, Sherpa Mingma Thsering, Yazaki Kai, Tanaka Ryota, Okiyama Naoko, Muratani Masafumi, Ishii Yukio, Hizawa Nobuyuki
Abstract excerpt
The programmed cell death-1 (PD-1) and programmed cell death-ligand 1 (PD-L1) pathway could affect antimicrobial immune responses by suppressing T cell activity. Several recent studies demonstrated that blocking of the PD-1/PD-L1 pathway exacerbated Mycobacterium tuberculosis infection. However, the effect of blocking this pathway in pulmonary Mycobacterium avium-intracellulare complex (MAC) infection is not...
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