Article
Innate immunity to viruses: control of vaccinia virus infection by gamma delta T cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 2001
Selin L K, Santolucito P A, Pinto A K, Szomolanyi-Tsuda E, Welsh R M
Abstract excerpt
The existence of gammadelta T cells has been known for over 15 years, but their significance in innate immunity to virus infections has not been determined. We show here that gammadelta T cells are well suited to provide a rapid response to virus infection and demonstrate their role in innate resistance to vaccinia virus (VV) infection in both normal C57BL/6 and beta TCR knockout (KO) mice. VV-infected mice...
Topics
- Animals
- Cell Movement
- Cytotoxicity Tests, Immunologic
- Cytotoxicity, Immunologic
- Epitopes, T-Lymphocyte
- Genes, T-Cell Receptor beta
- Genetic Predisposition to Disease
- Immunity, Cellular
- Immunity, Innate
- Kinetics
- Lymphocyte Activation
- Lymphocyte Count
- Lymphocyte Depletion