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Considerations, Caveats, and Suggestions for the Use of Polygenic Scores for Social and Behavioral Traits.

Behavior genetics - 1 Jan 2024

Non Amy L, Cerdeña Jessica P

Abstract excerpt

Polygenic scores (PGS) are increasingly being used for prediction of social and behavioral traits, but suffer from many methodological, theoretical, and ethical concerns that profoundly limit their value. Primarily, these scores are derived from statistical correlations, carrying no inherent biological meaning, and thus may capture indirect effects. Further, the performance of these scores depends upon the...

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PMID: 37801150
DOI: 10.1007/s10519-023-10162-x
PMCID: PMC10822803

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