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How Does Transcription-Associated Mutagenesis Shape tRNA Microevolution?

Genome biology and evolution - 2 Mar 2026

Baños Hector, Wang Ling, Simonti Corinne, Paaby Annalise B, Heitsch Christine

Abstract excerpt

Transfer RNAs (tRNAs) are among the most highly conserved and frequently transcribed genes. Recent studies have demonstrated that tRNAs experience exceptionally high rates of transcription-associated mutagenesis (TAM) as well as strong purifying selection. How the mutational input of TAM, which induces a nonuniform distribution of nucleotide substitutions, affects the fitness of tRNA molecules is unclear....

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Identifiers

PMID: 41784298
DOI: 10.1093/gbe/evag050
PMCID: PMC13034040

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