Article

Transfer RNA genes experience exceptionally elevated mutation rates

2017-12-06

Abstract excerpt

Transfer RNAs (tRNAs) are a central component for the biological synthesis of proteins, and they are among the most highly conserved and frequently transcribed genes in all living things. Despite their clear significance for fundamental cellular processes, the forces governing tRNA evolution are poorly understood. We present evidence that transcription-associated mutagenesis and strong purifying selection are key...

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Literature Corpus work: 1066bd05-5b09-549d-822d-cc9a2df009b0
DOI: 10.1101/229906

Open publication

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