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Allelic Variation at tRNA Genes in Three Nematode Species Indicates Mutation Load Despite Strong Purifying Selection.

Genome biology and evolution - 2 Mar 2026

Bell Avery Davis, Simonti Corinne, Baños Hector, Wang Ling, Heitsch Christine, Lachance Joseph, Paaby Annalise B

Abstract excerpt

Cytosolic transfer RNAs (tRNAs), which are encoded as hundreds of genes in nuclear genomes, experience exceptionally high mutation rates and have been hypothesized to confer substantial mutational load in natural populations. Although this phenomenon appears universal across multicellular eukaryotes, a comprehensive characterization of standing variation in tRNA repertoires is still lacking in any system. Here,...

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Identifiers

PMID: 41777052
DOI: 10.1093/gbe/evag053
PMCID: PMC13010820

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