Article

Allelic variation at tRNA genes in three nematode species indicates mutation load despite strong purifying selection

2025-10-15

Abstract excerpt

Cytosolic transfer RNAs, which are encoded as hundreds of genes in nuclear genomes, experience exceptionally high mutation rates and have been hypothesized to confer substantial mutational load in natural populations. Although this phenomenon appears universal across multicellular eukaryotes, a comprehensive characterization of standing variation in tRNA repertoires is still lacking in any system. Here, we resolve...

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Literature Corpus work: edd5d054-b9bc-569a-9422-958b199b0712
DOI: 10.1101/2025.10.14.682033

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