Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Relaxed sequence constraints favor mutational freedom in idiosyncratic metazoan mitochondrial tRNAs.

Nature communications - 20 Feb 2020

Kuhle Bernhard, Chihade Joseph, Schimmel Paul

Abstract excerpt

Metazoan complexity and life-style depend on the bioenergetic potential of mitochondria. However, higher aerobic activity and genetic drift impose strong mutation pressure and risk of irreversible fitness decline in mitochondrial (mt)DNA-encoded genes. Bilaterian mitochondria-encoded tRNA genes, key players in mitochondrial activity, have accumulated mutations at significantly higher rates than their cytoplasmic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Physiological
Share to Amino Acyl-tRNA Synthetases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Nucleic Acid Conformation

Share to RNA, Mitochondrial

Share to RNA Stability

Share to RNA, Transfer

Share to Static Electricity

Source

Open in PubMed Open full text

Identifiers

PMID: 32080176
DOI: 10.1038/s41467-020-14725-y
PMCID: PMC7033119

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Relaxed sequence constraints favor mutational freedom in idiosyncratic metazoan mitochondrial tRNAs.PMID 32080176Read ↗

Genetic code variations in mitochondria: tRNA as a major determinant of genetic code plasticity.Semantic proximity Read ↗

Back to Water: Signature of Adaptive Evolution in Cetacean Mitochondrial tRNAs.Semantic proximity Read ↗

Mitochondrial DNA in metazoa: degree of freedom in a frozen event.Semantic proximity Read ↗

Genome Size Reduction and Transposon Activity Impact tRNA Gene Diversity While Ensuring Translational Stability in Birds.Semantic proximity Read ↗

Rewiring the keyboard: evolvability of the genetic code.Semantic proximity Read ↗

Allelic variation at tRNA genes in three nematode species indicates mutation load despite strong purifying selectionSemantic proximity Read ↗

Transfer RNA genes experience exceptionally elevated mutation ratesSemantic proximity Read ↗

Transfer RNA genes experience exceptionally elevated mutation rates.Semantic proximity Read ↗

Search for characteristic structural features of mammalian mitochondrial tRNAs.Semantic proximity Read ↗

Allelic Variation at tRNA Genes in Three Nematode Species Indicates Mutation Load Despite Strong Purifying Selection.Semantic proximity Read ↗

Mitochondrial tRNA sequences as unusual replication origins: pathogenic implications for Homo sapiens.Semantic proximity Read ↗

Mechanisms and convergence of compensatory evolution in mammalian mitochondrial tRNAs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.